COVID-19 and HIV-associated Nephropathies: Double Whammy

The number of COVID-19-associated nephropathies (COVAN) rapidly increased before the fourth wave of the COVID-19 pandemic. Similarities and common lesions with the HIV-associated nephropathy (HIVAN) remarkably affect mostly African Americans positive for the APOL1 risk variants;therefore, these cases must be prioritized in new targeted clinical trials. Copyright © 2022, Bentham Science Publishers. All rights reserved.

Plasma Exchange in Refractory Acute Disseminated Encephalomyelitis Associated with COVID-19: The Technical Challenges in a Developing Country

Evaluation of acquired demyelinating syndrome (ADS) without diagnostic biomarkers results in diagnostic and therapeutic challenges in pediatric population. Immune-mediated ADS of childhood responds well to steroid and intravenous immunoglobulin (IVIg) and in refractory cases with plasma exchange. Novel coronavirus disease 2019 (COVID-19) coinfection in such cases imposes technical challenges in management. An 11-year-old girl with quadriparesis and loss of vision and a magnetic resonance imaging (MRI) brain showing acute demyelinating encephalomyelitis (ADEM) and cerebrospinal fluid examination being noncontributory responded well with plasma exchange after failing steroid and IVIg is described. Coinfection with COVID-19 mandating personal protection in a temperate country imposed technical challenges in her management.